alpha-Synuclein knockout mice have cognitive impairments

作者：Kokhan V S^*; Afanasyeva M A; Van'kin G I

来源：Behavioural Brain Research, 2012, 231(1): 226-230.

DOI：10.1016/j.bbr.2012.03.026

• alpha-Synuclein
• Knockout mice
• Learning
• Memory

alpha-Synuclein is a member of the synuclein family of cytoplasmic, predominantly neuron-specific proteins. Considerable amount of alpha-synuclein is found in axons and presynaptic terminals of neurons located in brain areas responsible for emotions and memory. In the present study we have carried out behavioral evaluation of spatial and working long-term memory of alpha-synuclein knockout mice. Our data shows that alpha-synuclein knockout mice have reduced learning ability in tests requiring both working and spatial memory. For the first time we have demonstrated that alpha-synuclein is necessary for these types of learning.

• 出版日期2012-5-16