Direct Substitution of Hydroxy Group of pi-Activated Alcohols with Electron-Deficient Amines Using Re2O7 Catalyst

作者：Das Braja Gopal; Nallagonda Rajender; Ghorai Prasanta^*

来源：Journal of Organic Chemistry, 2012, 77(13): 5577-5583.

DOI：10.1021/jo300706b

The first example of simple Re2O7-catalyzed direct dehydrative coupling between allylic alcohols with electron-deficient amines has been achieved under mild and open flask conditions. The protocol has also been successfully applied to benzylic and propargylic alcohols. The mechanistic proof for the S(N)1-type process has also been provided.

• 出版日期2012-7-6