Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract

作者：Shang, Xiaofei; Wang, Jinhui; Li, Maoxing^*; Miao, Xiaolou; Pan, Hu; Yang, Yaoguang; Wang, Yu

来源：Fitoterapia, 2011, 82(4): 716-721.

DOI：10.1016/j.fitote.2011.03.001

• Phlomis umbrosa Turcz
• Aqueous extract
• Antinociceptive activity
• Anti-inflammatory activity

Phlomis umbrosa Turcz has been used as the traditional medicine for thousands of years in China. In this paper, the acetic acid-induced writhing test, the hot plate test, the carrageenan-induced paw edema test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage and leukocyte infiltration test were used to investigate the antinociceptive and anti-inflammatory activities of the aqueous extract of this plant (25, 50 and 100 mg/kg i.p.). Good dose-dependent effects were obtained in most of these tests, except in the hot plate test and the acetic acid-induced Evans blue leakage test. TLC and HPLC analyses showed iridoid glucosides were the main compositions of this extract. These findings suggested that the aqueous extract of P. umbrosa has significant antinociceptive and anti-inflammatory activities.

• 出版日期2011-6
• 单位中国人民解放军兰州军区兰州总医院; 甘肃中医药大学; 中国农业科学院