Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects

作者：Barra Gustavo Barcelos^*; Sanches Dutra Ludmila Alves; Watanabe Silvia Conde; Garcia Costa Patricia Godoy; Marques da Cruz Patricia Sales; Azevedo Monalisa Ferreira; Amato Angelica Amorim

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2012, 56(8): 479-484.

DOI：10.1590/S0004-27302012000800003

• TCF7L2
• single nucleotide polymorphism
• type 2 diabetes
• rs7903146

Objective: To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. Subjects and methods: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. Results: We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). Conclusion: These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds. Arq Bras Endocrinol Metab. 2012;56(8):479-84

• 出版日期2012-11