Antihyperlipidemic Effect of Protodioscin, an Active Ingredient Isolated from the Rhizomes of Dioscorea nipponica

作者：Wang, Tiejie; Choi, Roy C. Y.; Li, Jun; Li, Jun; Bi, Cathy W. C.; Zang, Linquan; Liu, Zhongbo; Dong, Tina T. X.; Bi, Kaishun; Tsim, Karl W. K.^*

来源：Planta Medica, 2010, 76(15): 1642-1646.

DOI：10.1055/s-0030-1249960

• Dioscorea nipponica Makino
• Disocorea L.
• Dioscoreaeceae
• protodoscin
• hyperlipidemic

Developing drugs against metabolic-related disorders, including obesity and hyperlipidemia, is of importance for human health. Here, a bioactive phytochemical, protodioscin, isolated from the rhizomes of Dioscorea nipponica (Rhizoma Dioscoreae Nipponicae), was identified for its antihyperlipidemic effect. In hyperlipidemic rats, the post-administration of protodioscin significantly reduced the time of blood coagulation. In addition, the blood levels of triglyceride, cholesterol, low-density and high-density lipoproteins were also changed accordingly. Taken together, this was the first report of an antihyperlipidemic effect of protodioscin. Its great availability in various vegetables and medicinal plants will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.

• 出版日期2010-10
• 单位沈阳药科大学; 深圳市药品检验研究院; 香港科技大学; 广东药科大学