A form of synaptically induced metabotropic glutamate receptor-dependent long-term depression that does not require postsynaptic calcium

作者：Kasten Michael R; Connelly Timothy^*; Fan Yuan; Schulz Paul E

来源：Neuroscience Letters, 2012, 511(1): 12-17.

DOI：10.1016/j.neulet.2012.01.003

• CA1
• Hippocampus
• LTP
• LTD
• mGluR
• Plasticity

The calcium control hypothesis posits that postsynaptic calcium increases are required to trigger synaptic plasticity, with large increases inducing LTP and small increases inducing LTD. In CA1 of the hippocampus, however, LTD induced by chemical activation of metabotropic glutamate receptors (agonist-LTD) is independent of increases in postsynaptic calcium. Here we tested whether LTD induced by pairing of presynaptic stimulation with postsynaptic depolarization (synaptic-LTD) is similarly calcium-independent. This protocol induced an NMDA-dependent LTP when paired at 0 mV, which was converted to mGluR-dependent LTD when paired at 20 mV. The LTD was not blocked by calcium chelation, blockers of L- or T-type voltage-dependent calcium channels, or hyperpolarization to 70 mV. We conclude that synaptically induced mGluR-dependent LTD, like agonist induced mGluR LTD, does not require calcium influx for its induction.

• 出版日期2012-3-5