Affective temperaments in clinical practice: A validation study in mood disorders

作者：Voehringer P A; Whitham E A; Thommi S B; Holtzman N S; Khrad H; Ghaemi S N^*

来源：Journal of Affective Disorders, 2012, 136(3): 577-580.

DOI：10.1016/j.jad.2011.10.028

• Temperament
• TEMPS-A
• Treatment outcomes
• Mood disorders

Background: We sought to examine correlations between clinical validators and temperaments in clinical practice. %26lt;br%26gt;Methods: We provided the self-report TEMPS-A (50 item long) to 123 consecutive patients seen in the Mood Disorders Program of Tufts Medical Center. Temperament was assessed as cyclothymia, dysthymia, irritable or hyperthymia. Cut-offs were tested using (50%) and (75%) thresholds of affirmative responses, as well as highest percent for dominant temperament. We reported no dominant temperament at 75% cut-off. Multivariate regression modeling was conducted to assess confounding bias. %26lt;br%26gt;Results: Using clinical and demographic validators, cyclothymia was the most strongly validated temperament, followed by dysthymia and hyperthymia. Irritable temperament did not appear to be valid in this sample. A 75% item endorsement cut-off appeared to identify clinically important temperaments in slightly less than half of this sample. Those without any temperament at 75% cut-off had better prognostic features. 50% cut-off was highly nonspecific, and poorly correlated with diagnostic validators. %26lt;br%26gt;Conclusions: Affective temperaments correlate with clinical validators, most robustly for cyclothymia. 75% cut-off on the TEMPS may provide a useful categorical definition of abnormal affective temperaments in mood disorders. With that definition, slightly less than one-half of patients with mood disorders have affective temperaments. Those without abnormal affective temperaments have better prognostic features.

• 出版日期2012-2