An Efficient Copper-Catalyzed Microwave-Assisted S-Arylation towards the Synthesis of 8-Arylsulfanyl Adenines

作者：Sun Weilin; Patel Pallav D; Stephani Ralph A; Chiosis Gabriela^*

来源：Synlett, 2011, (20): 3008-3012.

DOI：10.1055/s-0031-1289888

• microwave
• copper-catalyzed S-arylation
• phase-transfer catalyst

We report a microwave-assisted synthetic protocol for the C-S cross-coupling reaction of aryl iodides and 8-mercaptoadenine using CuI and n-Bu4NBr with NaOt-Bu in DMF. The method is rapid, simple, and cost efficient, and leads in high yields to biologically relevant aryl sulfides.

• 出版日期2011-12