Iridium-Catalyzed Direct C-H Amination with Alkylamines: Facile Oxidative Insertion of Amino Group into Iridacycle

作者：Kim Hyunwoo; Chang Sukbok^*

来源：ACS Catalysis, 2015, 5(11): 6665-6669.

DOI：10.1021/acscatal.5b02165

• iridium catalysis
• C-H amination
• alkylamines
• oxidative coupling
• cross-dehydrogenative coupling

Described herein is the development of Cp*Ir-(III)-catalyzed direct arene C-H amination using alkylamines as an amino source. This C-N bond formation showcases a notable example of cross-dehydrogenative coupling to install an amino functionality at the ortho-position of benzamide substrates. Mechanistic studies including the isolation of an amine-bound iridacyclic intermediate along with a set of chemical oxidations demonstrated the Ir-catalyzed inner-sphere C-H amination with primary alkylamines for the first time.

• 出版日期2015-11