Argon: Systematic Review on Neuro- and Organoprotective Properties of an %26quot;Inert%26quot; Gas

作者：Hoellig Anke; Schug Anita; Fahlenkamp Astrid V; Rossaint Rolf; Coburn Mark^*

来源：International Journal of Molecular Sciences, 2014, 15(10): 18175-18196.

DOI：10.3390/ijms151018175

• argon
• neuroprotection
• organoprotection
• inert gas
• hypoxia
• ischemia
• cytoprotection

Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in vitro models for ischemic pathologies to investigate the effect of argon treatment. Promising data has been published concerning pathologies like cerebral ischemia, traumatic brain injury and hypoxic ischemic encephalopathy. However, models applied and administration of the therapeutic gas vary. Here we provide a systematic review to summarize the available data on argon%26apos;s neuro- and organoprotective effects and discuss its possible mechanism of action. We aim to provide a summary to allow further studies with a more homogeneous setting to investigate possible clinical applications of argon.

• 出版日期2014-10