Nickel-Catalyzed Reductive Couplings

作者：Wang, Xuan; Dai, Yijing; Gong, Hegui^*

来源：TOPICS IN CURRENT CHEMISTRY, SPRINGER INTERNATIONAL PUBLISHING AG, GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND, 43, 2016-08.

DOI：10.1007/s41061-016-0042-2

• Reductive coupling
• Nickel catalysis
• Electrophiles
• Selectivity

The Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be an important protocol for the construction of C-C bonds. This chapter first emphasizes the recent progress on the Ni-catalyzed alkylation, arylation/vinylation, and acylation of alkyl electrophiles. A brief overview of CO2 fixation is also addressed. The chemoselectivity between the electrophiles and the reactivity of the alkyl substrates will be detailed on the basis of different Ni-catalyzed conditions and mechanistic perspective. The asymmetric formation of C(sp(3))-C(sp(2)) bonds arising from activated alkyl halides is next depicted followed by allylic carbonylation. Finally, the coupling of aryl halides with other C(sp(2))-electrophiles is detailed at the end of this chapter.

• 出版日期2016-8
• 单位同济大学; 上海大学