Memory T cells skew toward terminal differentiation in the CD8+T cell population in patients with acute myeloid leukemia

作者：Xu, Ling; Yao, Danlin; Tan, Jiaxiong; He, Zifan; Yu, Zhi; Chen, Jie; Luo, Gengxin; Wang, Chunli; Zhou, Fenfang; Zha, Xianfeng; Chen, Shaohua; Li, Yangqiu^*

来源：Journal of Hematology & Oncology, 2018, 11(1): 93.

DOI：10.1186/s13045-018-0636-y

• Stem cell memory T cells
• Central memory T cells
• Effector memory T cells
• CD8+T cells
• Acute myeloid leukemia
• Bone marrow
• Peripheral blood

Stem cell memory T (T-SCM) and central memory T (T-CM) cells can rapidly differentiate into effector memory (T-EM) and terminal effector (T-EF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of T-SCM and T-CM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in T-SCM and T-CM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.

• 出版日期2018-7-9
• 单位暨南大学