A novel colorimetric and ratiometric fluorescent Cu2+ sensor based on hydrazone bearing 1,8-naphthalimide and pyrrole moieties

作者：Wang, Yuan; Mao, Pan-Dong; Wu, Wei-Na^*; Mao, Xian-Jie; Zhao, Xiao-Lei^*; Xu, Zhou-Qing; Fan, Yun-Chang; Xu, Zhi-Hong

来源：Sensors and Actuators B: Chemical , 2017, 251: 813-820.

DOI：10.1016/j.snb.2017.05.134

• Cu2+
• Pyrrole
• Naphthalimide
• Hydrazone
• Ratiometric fluorescent probe

A 1,8-naphthalimide hydrazone derivative bearing a pyrrole unit is a highly selective ratiometric fluorescent Cu2+ probe used to monitor intracellular Cu2+ in HeLa cells. This probe functions via a unique hydrolysis mechanism through Cu2+-promoted electrophilic substitution. Binding is confirmed through UV-vis absorption, fluorescence measurements, mass spectroscopy, IR, X-ray single crystal diffraction, and DFT calculation.

• 出版日期2017-11
• 单位许昌学院; 河南理工大学