Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn%26apos;s Disease

作者：Thachil Elodie; Hugot Jean Pierre; Arbeille Brigitte; Paris Regine; Grodet Alain; Peuchmaur Michel; Codogno Patrice; Barreau Frederick; Ogier Denis Eric; Berrebi Dominique; Viala Jerome^*

来源：Gastroenterology, 2012, 142(5): 1097-+.

DOI：10.1053/j.gastro.2012.01.031

• Secretion
• Lysosome
• Organelle

Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn%26apos;s disease (CD). However, little is known about the role of autophagy in CD. Intestinal biopsies from untreated pediatric patients with CD, celiac disease, or ulcerative colitis were analyzed by immunohistochemistry and electron microscopy. We observed that autophagy was specifically activated in Paneth cells from patients with CD, independently of mucosal inflammation or disease-associated variants of ATG16L1 or IRGM. In these cells, activation of autophagy was associated with a significant decrease in number of secretory granules and features of crinophagy. These observations might account for the disorganization of secretory granules previously reported in Paneth cells from patients with CD.

• 出版日期2012-5