Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: A pilot clinical study

作者：Lencioni Riccardo^*; Crocetti Laura; Petruzzi Pasquale; Vignali Claudio; Bozzi Elena; Della Pina Clotilde; Bargellini Irene; Cion Dania; Oliveri Filippo; De Simone Paolo; Bartolozzi Carlo; Brunetto Maurizia; Filipponi Franco

来源：Journal of Hepatology, 2008, 49(2): 217-222.

DOI：10.1016/j.jhep.2008.03.021

• hepatocellular carcinoma
• radiofrequency ablation
• doxorubicin

Background/Aims: Experimental studies have shown synergy between radiofrequency (RF) ablation and adjuvant chemotherapy in animal turnout models. We aimed to assess safety and efficacy of doxorubicin-eluting bead (DEB)-enhanced RF ablation in the treatment of human hepatocellular carcinoma (HCC).
Methods: Twenty patients with single HCC ranging 3.3-7.0 cm (mean, 5.0 cm +/- 1.4) showing evidence of residual viable tumour after standard RF ablation underwent intraarterial DEB administration (50-125 mg doxorubicin; mean, 60.2 mg +/- 21.8). Follow-up period ranged 6-20 months (mean, 12 months +/- 5).
Results: No major complication occurred. No deterioration of liver function was observed. The volume of treatment-induced necrosis - as measured on imaging - increased from 48.1 cm(3) +/- 35.7 after RF ablation to 75.5 cm(3) + 52.4 after DEB administration, with an increase of 60.9% +/- 39.0. The enhanced effect resulted in confirmed complete response (CR) of the target lesion in 12 (60%) of 20 patients. Incomplete response with persistence of <10% of initial turnout volume was observed in 6 (30%) of 20 patients, and local turnout progression in 2 (10%) of 20.
Conclusions:Intraarterial DEB administration substantially enhances the effect of RF ablation. DEB-enhanced RF ablation is safe and results in a high rate of CR in patients refractory to standard RF treatment.

• 出版日期2008-8