Low dose risperidone attenuates cue-induced but not heroin-induced reinstatement of heroin seeking in an animal model of relapse

作者：Lai Miaojun; Chen Weisheng; Zhu Huaqiang; Zhou Xiaoli; Liu Huifen; Zhang Fuqiang; Zhou Wenhua^*

来源：International Journal of Neuropsychopharmacology, 2013, 16(7): 1569-1575.

DOI：10.1017/S1461145712001563

• 5-HT2A receptors
• atypical antipsychotic drug
• dopamine
• opiate
• serotonin

The aim of the present study was to investigate the effects of pretreatment with risperidone on heroin self-administration and heroin-seeking behaviour induced by cues and heroin priming. Rats were trained to self-administer heroin under a fixed ratio 1 schedule for 2 wk and nose-poke responding was extinguished for 10 d, after which reinstatement of drug seeking was induced by conditioned cues or heroin priming. Acute risperidone administration at doses 10-100 mu g/kg potently and dose-dependently inhibited reinstatement of conditioned cue-induced heroin seeking; the minimum dose of inhibition was 30 mu g/kg. In contrast, risperidone at the same doses did not attenuate reinstatement induced by two priming doses of heroin (100 or 250 mu g/kg s.c.). Risperidone at these doses failed to alter heroin self-administration and locomotion activity. These data demonstrate that acute treatment with low-dose risperidone inhibits conditioned cue-induced heroin seeking and risperidone may be an adjunctive therapy for the treatment of heroin addiction.

• 出版日期2013-8
• 单位宁波大学