A bioorganometallic chemistry perspective: Organometallic chemistry at the interface with biology

作者：Fish Richard H^*

来源：Journal of Organometallic Chemistry, 2015, 782: 3-16.

DOI：10.1016/j.jorganchem.2014.10.034

• Bioorganometallic chemistry overview Cp*Rh-DNA
• GPCR peptides
• hydroxytamoxifen complexes
• bioorganotin chemistry Host-guest chemistry
• biomimetic co-factors
• co-factor regeneration
• and Organometallic chemistry compatibility with redox enzymes

A 41 year perspective on our bioorganometallic chemistry studies that included reactions of organotin compounds with cytochrome P450 enzymes, and their biomimics; identification of natural organoarsenic compounds in oil shale; reactions of an Cp*Rh tris aqua complex with nucleobases; supramolecular Cp*Rh-nucleobase complexes in host-guest chemistry; chemoselective reduction of NAD(+) biomimetic co-factors with an Cp*Rh-hydride to provide 1,4-NADH biomimics, in tandem with enzymatic catalysis for stereoselective reductions of achiral ketones to chiral alcohols, and including oxidation reactions with cytochrome P450 enzymes; synthesis and bioassays of organorhodium-hydroxytamoxifen breast cancer pharmaceuticals; and synthesis and bioactivity of Cp*Rh-G-Protein Coupled Receptor peptides, will be presented in this 2014 ISBOMC Award Paper.

• 出版日期2015-4-15