Aberrant expression of beta-catenin in CD4(+) T cells isolated from primary progressive multiple sclerosis patients

作者：Giacoppo Sabrina; Bereshchenko Oxana; Bruscoli Stefano; Riccardi Carlo; Bramanti Placido; Mazzon Emanuela^*

来源：Neuroscience Letters, 2017, 653: 159-162.

DOI：10.1016/j.neulet.2017.05.057

• beta-catenin
• Primary progressive multiple sclerosis
• Wnt-1
• CD4+T cells

Primary progressive multiple sclerosis (PP-MS) is a less common progressive form of MS in approximately 10% of patients that manifest increasingly neurological disability from disease onset. To date, there are no approved treatments for the' progressive stage. Therefore, identifying new therapeutic targets could open a new opportunity for PP-MS management. Several lines of evidence suggest the critical role of the Wnt/beta-catenin pathway in immune-mediated diseases, like MS.
This study was aimed to investigate whether aberrant expression of beta-catenin is involved in PP-MS progression.
By western blot analysis the expression of beta-catenin was evaluated in CD4(+) cells purified from peripheral blood of PP-MS patients.
Specifically, nuclear expression of beta-catenin was detected in CD4(+) T cells purified from peripheral blood lymphocytes of PP-MS, and not of other neuromuscular diseases. In addition, no relevant expression of Wnt-1 was found in PP-MS patients, suggesting that the increase in nuclear beta-catenin expression in these cells could be independent from canonical Wnt pathway.

• 出版日期2017-7-13