Anatomic Pathology of Hepatocellular Carcinoma Histopathology Using Classic and New Diagnostic Tools

作者：Pittman Meredith E; Brunt Elizabeth M^*

来源：Clinics in Liver Disease, 2015, 19(2): 239-+.

DOI：10.1016/j.cld.2015.01.003

• Hepatocellular carcinoma
• Liver biopsy
• Dysplastic nodule
• lmmunohistochemistry
• Glypican-3
• Glutamine synthetase
• Arginase-1
• Biphenotypic

Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.

• 出版日期2015-5