Second Primary Melanoma: Risk Factors, Histopathologic Features, Survival, and Implications for Follow-Up

作者：Jones Maris S; Torisu Itakura Hitoe; Flaherty Devin C; Schoellhammer Hans F; Lee Jihey; Sim Myung Shim; Faries Mark B

来源：American Surgeon, 2016, 82(10): 1009-1013.

DOI：10.1177/000313481608201034

<jats:p> The impact on survival of a second primary melanoma (SPM) is unclear. We used our melanoma center's database to examine clinicopathologic risk factors and outcomes of stage 0 to IV cutaneous melanoma in patients with one versus two primaries. Among 12,325 patients with primary melanoma, 969 (7.86%) developed SPM. SPMs were significantly thinner than autologous primary melanomas ( P = 0.01), and 451 SPM patients had better overall and melanoma-specific survival than 451 prognostically matched non-SPM patients ( P &lt; 0.0001 and 0.0001, respectively) at a median follow-up of 142.37 months. Patients with cutaneous melanoma are at high risk for development of SPM, but the development of SPM does not seem to impair survival. </jats:p>

• 出版日期2016-10