Assessment of Sex Differences in Plaque Morphology by Coronary Computed Tomography Angiography-Are Men and Women the Same?

作者：Grunau Gilat L^*; Ahmadi Amir; Rezazadeh Saman; Faraji Reza; Amid Sima; O'Connell Tim; Heilbron Brett; Leipsic Jonathon; Taylor Carolyn M

来源：Journal of Women's Health, 2014, 23(2): 146-150.

DOI：10.1089/jwh.2013.4496

Purpose: The objective of this study was to assess whether sex differences exist in plaque burden and plaque subtype as assessed by coronary computed tomography angiography (CCTA). Methods: The study cohort included 937 consecutive patients who underwent CCTA between 2008 and 2010. Stenosis was quantified using the Society of Cardiovascular Computed Tomography stenosis grading scale and a total stenosis score (TSS) was generated. Plaque morphology (PM) was reported as predominantly calcified (CP), noncalcified (NCP), or mixed (MP) plaque, and CP, NCP, and MP percentages were calculated. Results: On multivariate analysis, men were significantly more likely to have plaque (65.9% of men vs. 44.6% of women, p<0.001), at least one segment with 50% stenosis (22.7% of men vs. 10.3% of women, p<0.001) and higher TSS (mean score=2.81 for men vs. 1.58 for women, p<0.001). Sex was the strongest predictor in all models (odds ratio [OR]=2.55, 95% confidence interval [CI] 1.78-3.67, p<0.001 for any plaque; OR=2.48, 95% CI 1.48-4.16, p<0.01 for segments with 50% stenosis; =1.46, 95% CI 0.69-2.22, p<0.001 for TSS). Among patients with coronary plaque present, no significant sex differences in PM were found. Conclusions: Sex was the strongest risk factor for the presence and extent of plaque. Significant sex differences in PM did not exist.

• 出版日期2014-2-1