Association between restless legs syndrome and migraine: a population-based study

作者：Zanigni Stefano^*; Giannini Giulia; Melotti Roberto; Pattaro Cristian; Provini Federica; Cevoli Sabina; Facheris Maurizio F; Cortelli Pietro; Pramstaller Peter P

来源：European Journal of Neurology, 2014, 21(9): 1205-1210.

DOI：10.1111/ene.12462

• comorbidity
• headache
• migraine
• restless legs syndrome
• sleep disorders

Background and purpose: A higher prevalence of restless legs syndrome (RLS) in migraineurs has been reported in clinical samples and in two large-scale clinical trials performed on healthcare workers but general population-based studies on this topic are lacking. The aim of this study was to assess the association between migraine and RLS in an Italian rural adult population-based setting. %26lt;br%26gt;Methods: The presence of migraine and RLS was assessed via a computer-assisted personal interview and self-administered questionnaires according to current diagnostic criteria in 1567 participants of a preliminary phase of an adult population-based study performed in South Tyrol, Italy. %26lt;br%26gt;Results: Migraineurs had an increased risk of having RLS also after adjustment for confounding factors such as age, sex, major depression, anxiety and sleep quality (odds ratio 1.79; confidence interval 1.00-3.19; P = 0.049). This association was not modified by aura status and possible causes of secondary RLS. RLS was not significantly associated with tension-type headache. %26lt;br%26gt;Conclusions: Restless legs syndrome and migraine were associated in our rural adult population. This association could be explained by a possible shared pathogenic pathway which would implicate new management strategies of these two disorders.

• 出版日期2014-9