Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease

作者：Kelley Jim L; Ozment Tammy R; Li Chuanfu; Schweitzer John B; Williams David L^*

来源：Critical Reviews in Immunology, 2014, 34(3): 241-261.

DOI：10.1615/critrevimmunol.2014010267

• Scavenger receptor-A
• CD204
• inflammation
• sepsis
• infection
• innate immunity
• atherosclerosis
• brain and heart ischemia
• reperfusion injury

Scavenger receptor A (SR-A), also known as the macrophage scavenger receptor and cluster of differentiation 204 (CD204), plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. However, recent evidence points to important roles for SR-A in inflammation, innate immunity, host defense, sepsis, and ischemic injury. Herein, we review the role of SR-A in inflammation, innate immunity, host defense, sepsis, cardiac and cerebral ischemic injury, Alzheimer's disease, virus recognition and uptake, bone metabolism, and pulmonary injury. Interestingly, SR-A is reported to be host protective in some disease states, but there is also compelling evidence that SR-A plays a role in the pathophysiology of other diseases. These observations of both harmful and beneficial effects of SR-A are discussed here in the framework of inflammation, innate immunity, and endoplasmic reticulum stress.

• 出版日期2014