Assessment of the sensitivity of the gamma-interferon test and the single intradermal comparative cervical test for the diagnosis of bovine tuberculosis under field conditions

作者：Praud A^*; Boschiroli M L; Meyer L; Garin Bastuji B; Dufour B

来源：Epidemiology and Infection, 2015, 143(1): 157-166.

DOI：10.1017/S0950268814000338

• Bayesian analysis
• tuberculosis (TB)
• screening programme

In some French departements, the eradication of bovine tuberculosis is incomplete and usual skin tests [single intradermal tuberculin test (SIT) and single intradermal comparative cervical test (SICCT)] have poor specificity due to cross-reactions with non-pathogenic mycobacteria, causing economic losses. In Cote d'Or (Burgundy, France), an experimental serial testing scheme based on the combination of SICCT and gamma-interferon (IFN-) tests has been initiated in order to shorten the interval between suspicion and its invalidation in herds with false-positive results to skin tests. Our aim was to assess the scheme's sensitivity and to compare it to the sensitivity of the screening scheme recommended by the European Commission. Our study included 1768 animals from Cote d'Or. The sensitivities of both schemes were estimated using a Bayesian approach. The individual sensitivity of the IFN- test [881%, 95% credibility interval (CrI) 728-975] was not significantly different from individual SICCT sensitivity (803%, 95% CrI 616-980) and individual SIT sensitivity (842%, 95% CrI 590-982). The individual specificity of the IFN- test was 623% (95% CrI 602-645). No significant difference could be demonstrated between the sensitivities of the serial testing scheme used in Cote d'Or (731%, 95% CrI 411-100) and the European Union serial testing scheme (701%, 95% CrI 315-1000).

• 出版日期2015-1