A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation

作者：Yun Seong Wook; Leong Cheryl; Bi Xuezhi; Ha Hyung Ho; Yu Yuan Hong; Tan Yee Ling; Narayanan Gunaseelan; Sankaran Shvetha; Kim Jun Young; Hariharan Srivats; Ahmed Sohail^*; Chang Young Tae

来源：Chemical communications, 2014, 50(56): 7492-7494.

DOI：10.1039/c4cc02974g

We report here a novel fluorescent chemical probe CDy5 which stains distinct neural stem/progenitor cells (NSPCs) by binding to acid ceramidase in mouse neurospheres. CDy5 is distributed evenly or unevenly to the daughter cells during multiple mitoses enabling the live imaging of symmetric and asymmetric divisions of isolated NSPCs.

• 出版日期2014
• 单位河北医科大学