Association Between-1562C > T Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 and Coronary Artery Disease: A Meta-Analysis

作者：Zhang, Feng-Xiang; Sun, Da-Peng; Guan, Ning; Chen, Jun-Jiang; Huo, Xiao-Chuan; Luo, Jun-Sheng^*

来源：Genetic Testing and Molecular Biomarkers, 2014, 18(2): 98-105.

DOI：10.1089/gtmb.2013.0369

• GELATINASE-B-GENE
• MATRIX METALLOPROTEINASES
• FUNCTIONAL POLYMORPHISM
• MYOCARDIAL-INFARCTION
• STROMELYSIN PROMOTER
• INCREASED RISK
• MMP-9 GENE
• ATHEROSCLEROSIS
• EXPRESSION
• VARIANTS

Aims: The present study was undertaken to determine the association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease (CAD) risk. Methods: This meta-analysis was on the basis of 26 studies that included 12,776 cases and 6371 controls, heterogeneity of which was assessed by the Q-statistic test and the I-2-statistic test. Sensitivity analysis was conducted by sequentially omitting any single study and recalculating the odds ratios (ORs) and 95% confidence intervals (CIs). Funnel plots and Egger's test were performed to test the potential publication bias. All data were analyzed by using STATA version 12.0. Results: We found that -1562C>T polymorphism did not contribute to the risk of CAD in the overall results. But the stratified analysis by ethnicity indicated that -1562C>T polymorphism might decrease susceptibility to CAD in Asians (OR, 0.94; 95% CI, 0.88-1.00; p(h)=0.956 for CC vs. CT+TT). Conclusions: Our meta-analysis supports the fact that -1562C>T polymorphism may have association with CAD risk in Asian populations. But further larger studies are required to confirm our findings.

• 出版日期2014-2-1