科研之友
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摘要
In this study, highly monodispersed Cu2SnZnS4 NCs with a quasi-spherical structure were prepared to construct a sandwich-type electrochemical immunosensor for alpha-fetoprotein detection. Quaternary Cu2SnZnS4 NCs as novel biomimetic catalysts show an efficient intrinsic peroxidase-like activity for H2O2 reduction. This excellent catalytic activity is ascribed to the higher electroconductivity than those of the binary Cu2S and ternary Cu2SnS3 NCs. Moreover, beta-cyclodextrin-functionalized graphene sheets are used as substrate materials that can capture large amounts of primary antibodies due to host-guest interaction and high surface area. Under the optimized conditions, the electrochemical immunosensor exhibites a wide working range from 0.5 pg mL(-1) to 10 ng mL(-1) and a detection limit of 0.16 pg mL(-1) at a signal-to-noise ratio of 3. Good sensitivity, reproducibility, and stability demonstrate its potential application in clinical diagnostics.
- 出版日期2017-3-7
- 单位中国地质大学（北京）
