Detoxification process of tolaasins, lipodepsipeptides, by Microbacterium sp K3-5

作者：Tomita Shun; Sue Masayuki; Kajikawa Akinobu; Igimi Shizunobu; Shinohara Hirosuke; Yokota Kenji^*

来源：Bioscience Biotechnology and Biochemistry, 2018, 82(8): 1455-1458.

DOI：10.1080/09168451.2018.1460575

• Tolaasin
• Pseudomonas tolaasii
• Microbacterium sp
• lipodepsipeptide
• antifungal activity

Tolaasins are antimicrobial lipodepsipeptides. Here, we report the tolaasins-detoxifying properties of Microbacterium sp. K3-5 (K3-5). The detoxification of tolaasins by K3-5 was performed by hydrolyzation of cyclic structure of tolaasins depending on the tolaasin-K3-5 cell interaction. Our data suggest that the cyclic structure of tolaasins is critical for its interaction to target cells.

• 出版日期2018