Diagnostic Accuracy of Cardiac 64-Slice Computed Tomography in Detecting Atrial Thrombi Comparative Study With Transesophageal Echocardiography and Cardiac Surgery

作者：Feuchtner Gudrun M^*; Dichtl Wolfgang; Bonatti Johannes O; Jodocy Daniel; Mueller Silvana; Hintringer Florian; Gradl Johannes; Klauser Andrea; Cury Ricardo C

来源：Investigative Radiology, 2008, 43(11): 794-801.

DOI：10.1097/RLI.0b013e318184cd6c

• cardiac multidetector computed tomography
• CT
• MDCT
• left atrial thrombi
• echocardiography
• atrial fibrillation

Objectives: Atrial thrombi are a potential source for cerebral and peripheral emboli. Objective of this study was to evaluate the diagnostic accuracy of 64-slice cardiac computed tomography (CT) for detection of atrial thrombi in comparison with transesophageal echocardiography (TEE) and cardiac surgery.
Material and Methods: Sixty-four patients were examined with ECG-gated multidetector CT coronary or pulmonary vein angiography. All patients underwent TEE. Cardiac surgery was performed in 31 patients. The Hounsfield units (HU) of atrial lesions were measured.
Results: The diagnostic accuracy of 64-slice CT for the detection of atrial thrombi was 77%: sensitivity 100% (9/9), specificity 73% (40/55), positive predictive value (PPV) 38% (9/24), and negative predictive value (NPV) 100% (40/40). All 15 false positive (FP) findings by CT were located in the left atrial appendage (LAA). Four characteristic imaging features suggesting incomplete filling of the LAA were noted in FP: "hypostatic layering," 5115 (33%); "flow phenomenon," 9/15 (60%); "HU-run-off," 8/15 (53%); higher intralesional HU in FP when compared with thrombi (153.8 HU +/- 71 vs. 46.6 HU +/- 10; P < 0.0001). The diagnostic accuracy of CT in detecting atrial thrombi improved significantly (P = 0.03) to 86% after defining "typical filling defects" as "flow phenomenon/> 180 HU" (sensitivity 100%; specificity 84%; PPV 50%; NPV 100%). On receiver operating curve (ROC) analysis, a threshold of 60.7 HU showed a specificity of 100% and a sensitivity of 86.7% to distinguish between FP and thrombi.
Conclusions: Cardiac ECG-gated 64-slice CT is accurate to exclude atrial thrombi, which can be applied eg, in patients before radiofrequency (RF) ablation. Left atrial appendage "filling defects" cause a high number of false positive findings, and there are radiologic features, which are helpful to differentiate them from true thrombi.

• 出版日期2008-11