摘要
Objectives To evaluate the effectiveness of the iterative decomposition of water and fat with echo asymmetric and least-squares estimation (IDEAL) MRI to quantify tumour infiltration into the lumbar vertebrae in myeloma patients without visible focal lesions. %26lt;br%26gt;Methods The lumbar spine was examined with 3 T MRI in 24 patients with multiple myeloma and in 26 controls. The fat-signal fraction was calculated as the mean value from three vertebral bodies. A post hoc test was used to compare the fat-signal fraction in controls and patients with monoclonal gammopathy of undetermined significance (MGUS), asymptomatic myeloma or symptomatic myeloma. Differences were considered significant at P%26lt;0.05. The fat-signal fraction and beta(2)-microglobulin-to-albumin ratio were entered into the discriminant analysis. %26lt;br%26gt;Results Fat-signal fractions were significantly lower in patients with symptomatic myelomas (43.9 +/- 19.7%, P%26lt;0.01) than in the other three groups. Discriminant analysis showed that 22 of the 24 patients (92%) were correctly classified into symptomatic or non-symptomatic myeloma groups. %26lt;br%26gt;Conclusions Fat quantification using the IDEAL sequence in MRI was significantly different when comparing patients with symptomatic myeloma and those with asymptomatic myeloma. The fat-signal fraction and beta(2)-microglobulin-to-albumin ratio facilitated discrimination of symptomatic myeloma from non-symptomatic myeloma in patients without focal bone lesions. %26lt;br%26gt;Key Points %26lt;br%26gt;A new magnetic resonance technique (IDEAL) offers new insights in multiple myeloma. %26lt;br%26gt;Fat-signal fractions were lower in patients with symptomatic myelomas than in those with asymptomatic myelomas. %26lt;br%26gt;The beta(2)-microglobulin-to-albumin ratio also aided discrimination of symptomatic myeloma. %26lt;br%26gt;The fat-signal fraction may provide information about the myeloma cell mass.
- 出版日期2012-5