Unrelated Donor Allogeneic Transplantation after Failure of Autologous Transplantation for Acute Myelogenous Leukemia: A Study from the Center for International Blood and Marrow Transplantation Research

作者：Foran James M; Pavletic Steven Z; Logan Brent R; Agovi Johnson Manza A; Perez Waleska S; Bolwell Brian J; Bornhaeuser Martin; Bredeson Christopher N; Cairo Mitchell S; Camitta Bruce M; Copelan Edward A; Dehn Jason; Gale Robert P; George Biju; Gupta Vikas; Hale Gregory A; Lazarus Hillard M; Litzow Mark R; Maharaj Dipnarine; Marks David I; Martino Rodrigo; Maziarz Richard T; Rowe Jacob M; Rowlings Philip A; Savani Bipin N; Savoie Mary Lynn

来源：Biology of Blood and Marrow Transplantation, 2013, 19(7): 1102-1108.

DOI：10.1016/j.bbmt.2013.04.022

• Acute myelogenous leukemia
• Unrelated donor
• Transplantation
• Allogeneic
• Autologous

The survival of patients with relapsed acute myelogenous leukemia (AML) after autologous hematopoietic stem cell transplantation (auto-HCT) is very poor. We studied the outcomes of 302 patients who underwent secondary allogeneic hematopoietic cell transplantation (allo-HCT) from an unrelated donor (URD) using either myeloablative (n = 242) or reduced-intensity conditioning (RIC; n = 60) regimens reported to the Center for International Blood and Marrow Transplantation Research. After a median follow-up of 58 months (range, 2 to 160 months), the probability of treatment-related mortality was 44% (95% confidence interval [CI], 38%-50%) at 1-year. The 5-year incidence of relapse was 32% (95% CI, 27%-38%), and that of overall survival was 22% (95% CI, 18%-27%). Multivariate analysis revealed a significantly better overal survival with RIC regimens (hazard ratio [HR], 0.51; 95% CI, 0.35-0.75; P %26lt; .001), with Karnofsky Performance Status score %26gt;= 90% (HR, 0.62; 95% CI, 0.47-0.82: P = .001) and in cytomegalovirus-negative recipients (HR, 0.64; 95% CI, 0.44-0.94; P = .022). A longer interval (%26gt;18 months) from auto-HCT to URD allo-HCT was associated with significantly lower riak of relapse (HR, 0.19; 95% CI, 0.09-0:38; P %26lt; .001) and improved leukemia-free survival (HR, 0.53; 95% CI, 0.34-0.84; P = .006). URD allo-HCT after auto-HCT relapse resulted in 20% long-term leukemia-free survival, with the best results seen in patients with a longer interval to secondary URD transplantation, with a Karnofsky Performance Status score %26gt;90%, in complete remission, and using an RIC regimen. Further efforts to reduce treatment-related mortaility and relapse are still needed.

• 出版日期2013-7