Diastereoselective and one-pot synthesis of highly substituted cyclohexenones using Claisen-Schmidt condensation and Michael addition

作者:Mousavi Mir Rasul*; Gharari Hadigheh; Maghsoodlou Malek Taher; Hazeri Nourallah; Dastorani Parvaneh; Soria Martinez Ruben; Garcia Granda Santiago
来源:Journal of Chemical Research, 2015, 39(9): 509-514.
DOI:10.3184/174751915X14396601175593

摘要

A high efficient and convenient one-pot three-component diastreoselective synthesis of polysubstituted cyclohexenones in excellent yields has been developed through Michael addition and Claisen-Schmidt condensation of aldehydes and acetophenone with 3-oxo-N-phenylbutanamide using piperidine as an effective reagent under mild conditions within sort reaction time without using any previous activation.

  • 出版日期2015-9