DIRECT OXIDATIVE CONVERSION OF ALDEHYDES INTO 2-SUBSTITUTED 1,4,5,6-TETRAHYDROPYRIMIDINES USING MOLECULAR IODINE OR 1,3-DIIODO-5,5-DIMETHYLHYDANTOIN

作者：Takahashi Shogo^*; Togo Hideo

来源：Heterocycles, 2010, 82(1): 593-601.

DOI：10.3987/COM-10-S(E)29

• 1,4,5,6-Tetrahydropyrimidine
• 1,3-Propanediamine
• Aldehyde
• Pyrimidine
• Iodine
• 1,3-Diiodo-5,5-dimethylhydantoin

Various aromatic and aliphatic aldehydes were efficiently converted into the corresponding 1,4,5,6-tetrahydro-2-arylpyrimidines and 1,4,5,6-tetrahydro-2-alkylpyrimidines in good yields by the reaction with 1,3-propanediamine in the presence of molecular iodine center dot K2CO3 or 1,3-diiodo-5,5-dimethylhydantoin. Those 1,4,5,6-tetrahydropyrimidines were oxidized to the corresponding 2-aryl- and 2-alkylpyrimidines in moderate yields using MnO2.

• 出版日期2010-12-31