Ameliorative effects of human adipose tissue-derived mesenchymal stem cells on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats

作者：Ko Myung Soon; Park Hyeong geun; Yun Young Min; Ra Jeong Chan; Shin Taekyun; Lee Kyoung Kap^*

来源：Neural Regeneration Research, 2011, 6(16): 1205-1210.

DOI：10.3969/j.issn.1673-5374.2011.16.001

• experimental autoimmune encephalomyelitis
• human adipose tissue
• mesenchymal stem cells
• interleukin-10
• interferon-gamma
• indoleamine 2, 3-dioxygenase
• neural regeneration

Mesenchymal stem cells have been previously shown to exert an immunomodulatory function. The present study sought to investigate the effects of multipotential human adipose tissue-derived mesenchymal stem cells (hAdMSCs) on disease progression and cytokine expression in Lewis rats with experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein. The duration of EAE paralysis in the group treated on day 7 postimmunization with 5 x 10(6) hAdMSCs was significantly reduced compared with the vehicle-treated controls and the 1 x 10(6) hAdMSC-treated group. The duration of EAE paralysis in the groups treated with 5 x 10(6) hAdMSCs on both day 1 and day 7 postimmunization was significantly reduced compared with the vehicle-treated controls and the groups treated with 5 x 10(6) hAdMSCs on both day 7 and day 10 postimmunization. The mRNA expression of interleukin-10 and indoleamine 2, 3-dioxygenase was significantly decreased in the hAdMSC-treated group compared with the vehicle-treated group. These findings suggest that the ameliorative effects of hAdMSCs on EAE symptoms operate in a dose-and time-dependent manner and can be mediated in part by the ample production of anti-inflammatory cytokines.

• 出版日期2011-7-25