Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters

作者：Afonso Damien; Valetti Sabrina; Fraix Aurore; Bascetta Claudia; Petralia Salvatore; Conoci Sabrina; Feiler Adam; Sortino Salvatore^*

来源：Nanoscale, 2017, 9(36): 13404-13408.

DOI：10.1039/c7nr04832g

Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.

• 出版日期2017-9-28