New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp.

作者：Ding, Bo; Yuan, Jie; Huang, Xishan; Wen, Weitao; Zhu, Xu; Liu, Yayue; Li, Hanxiang; Lu, Yongjun; He, Lei; Tan, Hongmei^*; She, Zhigang

来源：Marine Drugs, 2013, 11(12): 4961-4972.

DOI：10.3390/md11124961

• Mangrove
• Phomopsis sp
• Phomoxanthones
• phomolactonexanthones
• decetylphomoxanthone C
• MTT assay

Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 1-3 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cyctotoxic activities against tested cancer cell lines (IC50 < 10 M).

• 出版日期2013-12
• 单位中山大学