A Study on Prophylactic Efficacies of Daptomycin and Vancomycin in a Rat Model of MRSA Infection Secondary to Spinal Implantation

作者：Ozer Oner; Ozer Fusun D; Akcay Emrah; Atci Ibrahim Burak^*; Kocaman Umit; Ozinel Mehmet Ali; Vardar Ender; Ozdemir Nail

来源：Journal of Neurological Sciences-Turkish, 2013, 30(4): 767-775.

• Daptomycin
• infection
• spinal implantation
• vancomycin

The present study aims to investigate the prophylactic effects of daptomycin and vancomycin in an experimental spinal infection induced by spinal implantation. The study involved inoculation of a bacterial suspension prepared with the MRSA ATCC 43300 strain to the implant bed and to the peripheral tissue immediately the implantation of titanium spinal implants to the bone in adult Winstar rats. The animals were divided into three groups; seven rats in the first group received no antibiotics, while the seven rats in group two and eight rats in group three received daptomycin and vancomycin, respectively. Microbiological and histological assessments were carried out on rats with induced infections. %26lt;br%26gt;In the swab cultures of deep surgical areas, vancomycin demonstrated inhibition of infection of the surgical site in half of animals (50%) whereas daptomycin exhibited the same effect in more animals (71.4%), which was statistically significant compared to the control group (p%26lt;0.05). In the implant and bone culture, a statistically significant superiority was not observed in prophylactically treated with either antibiotic and nontreated control group (p%26gt;0.05). %26lt;br%26gt;As a result; comparing control group, preventive effects of daptomycin and vancomycin in infection induced model of spinal implantation with high bacteria inoculums were not found statistically significant whereas daptomycin showed statistically significant inhibition on deep surgical area infection.

• 出版日期2013