A study on the role of gelatin in methacrylic-acid-based gel dosimeters

作者：Hayashi Shin ichiro^*; Yoshioka Munenori; Usui Shuji; Haneda Kiyofumi; Kondo Takahiro; McAuley Kim B; Tominaga Takahiro

来源：Radiation Physics and Chemistry, 2010, 79(7): 803-808.

DOI：10.1016/j.radphyschem.2010.01.014

• Polymer gel
• Dosimetry
• MAGAT
• Temperature measurement
• MRI
• Radiotherapy

In radiotherapy treatment, polymer gel dosimetry can be used for verifying three-dimensional (3D) dose distributions. Gelatin is generally used as a gelling agent in the dosimeters. In this paper, another role of gelatin in a methacrylic-acid-based gel dosimeter (MAGAT) is investigated. Temperature increases due to exothermic polymerization in the irradiated gel are measured directly. Dose-R(2) responses are also obtained using MRI. It is shown that no appreciable increases in either temperature or R(2) are observed in MAGAT dosimeters made without gelatin, and that significant temperature and R(2) increases are observed when very low gelatin concentrations are used. These results indicate that gelatin is an important enabler for radiation-induced free-radical polymerization in methacrylic-acid-based gels. When gelatin is replaced by amino acids, changes in temperature are observed, along with small changes in R(2). The resulting dosimeter solutions remain transparent because the polymer does not precipitate as it does in regular MAGAT dosimeters containing gelatin. When the amino acids are replaced by acids without amino groups, no temperature or R(2) changes are observed, indicating that no polymer forms. These results show that amino groups (and possibly other functional groups) on the gelatin catalyze the radiation-induced free-radical polymerization that occurs in MAGAT dosimeters.

• 出版日期2010-7