Hybrid Multidimensional T-2 and Diffusion-Weighted MRI for Prostate Cancer Detection

作者：Wang Shiyang; Peng Yahui; Medved Milica; Yousuf Ambereen N; Ivancevic Marko K; Karademir Ibrahim; Jiang Yulei; Antic Tatjana; Sammet Steffen; Oto Aytekin; Karczmar Gregory S^*

来源：Journal of Magnetic Resonance Imaging, 2014, 39(4): 781-788.

DOI：10.1002/jmri.24212

• DWI
• TE
• T-2
• ADC
• multidimensional hybrid MRI
• prostate cancer

PurposeTo study the dependence of apparent diffusion coefficient (ADC) and T-2 on echo time (TE) and b-value, respectively, in normal prostate and prostate cancer, using two-dimensional MRI sampling, referred to as hybrid multidimensional imaging.
Materials and MethodsThe study included 10 patients with biopsy-proven prostate cancer who underwent 3 Tesla prostate MRI. Diffusion-weighted MRI (DWI) data were acquired at b=0, 750, and 1500 s/mm(2). For each b-value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T-2 were measured as a function of b-value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T-2 as a function of b-value.
ResultsIn normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (P=0.0003) and T-2 at b-value of 0 s/mm(2) is significantly longer than T-2 at b-value of 1500 s/mm(2) (P=0.001). In cancer ROIs, average ADC and T-2 values do not change as a function of TE and b-value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T-2 as a function of b-value. Cancers are more conspicuous in ADC maps at longer TEs.
ConclusionParameters derived from hybrid imaging that depend on coupled/associated values of ADC and T-2 may improve the accuracy of MRI in diagnosing prostate cancer. J. Magn. Reson. Imaging 2014;39:781-788.

• 出版日期2014-4