Anti-ulcer Activity of Sandalwood (Santalum album L.) Stem Hydroalcoholic Extract in Three Gastric-Ulceration Models of Wistar Rats

作者：Ahmed Nazeer; Ali Khan Mohammed Safwan^*; Mat Jais Abdul Manan; Mohtarrudin Norhafizah; Ranjbar Maryam; Amjad Mohammed Shujauddin; Nagaraju Bee; Faraz Mohammed; Pathan Faiyaz; Chincholi Anand

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2013, 12(1): 81-91.

• Hydro-alcoholic Extract from S. album Stem (SASE)
• anti-ulcer activity

Sandalwood (Santalum album L.) is used in various traditional systems of medicine, like Ayurveda, Siddha and Unani medicine to treat a wide range of ailments. In Unani medicine, Safed Sandal is used to treat gastric ulcers, hence the present study was undertaken to confirm this claim. A limit test as per OECD guidelines was conducted at a dose of 5000 mg/kg to determine the acute toxic dose of Hydro-alcoholic extract from S. album stem (SASE). Two test doses of SASE (250 and 500 mg/kg) were subjected to screening of anti-ulcer activity by three in-vivo models namely - water immersion - restrain stress, ethanol and indomethacin induced gastric ulceration models in albino wistar rats. A proton-pump inhibitor, Omeprazole 10 mg/kg and H-2 receptor antagonist, Ranitidine 50 mg/kg were employed as standard drugs. The results revealed an increase in gastric protection as a significant decrease (p %26lt; 0.001) in average number of ulcers, severity of ulcers and cumulative ulcer index was observed in the test groups. Histopathological evidences supported the above findings. The observed anti-ulcer effect of SASE at 500 mg/kg was comparable to that of standard drugs used in the experiments indicating significant anti-ulcer potential especially at higher concentration.

• 出版日期2013-1