An Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives under Catalyst-Free and Solvent-Free Conditions

作者:Gao Lijiu; Ji Honglou; Rong Liangce*; Tang Dan; Zha Yunyun; Shi Yanhui; Tu Shujiang
来源:Journal of Heterocyclic Chemistry, 2011, 48(4): 957-960.
DOI:10.1002/jhet.592

摘要

A simple, efficient and convenient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under solvent-free and catalyst-free conditions by the reaction of aromatic aldehydes, isatoic anhydride, and ammonium acetate was reported. The advantages of this protocol include short reaction time, mild reaction conditions, easy work-up, high yields, and environmental friendliness.