Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor a in human ovarian carcinoma cells

作者：Wang Chia Woei; Hsu Wei Hsuan; Tai Chen Jei

来源：Oncotarget, 2017, 8(2): 3049-3058.

DOI：10.18632/oncotarget.13829

• cordycepin
• mitochondrial fusion
• mitochondrial fission
• estrogen-related receptor (ERR)-alpha
• antimigration

Cordycepin (3'-deoxyadenosine) is a compound for antitumor, which has been found to exert antiangiogenic, antimetastatic, and antiproliferative effects, as well as inducing apoptosis. However, the association between cancer metastasis and mitochondrial activity in cordycepin-treated ovarian carcinoma cells remains unclear. The 50 and 100 mu M of cordycepin inhibits mitochondrial fusion and induces mitochondrial fission, respectively. These suggested that cordycepin showed the down-regulation of mitochondrial function and limitation of energy production. Because of activation of mitochondria and generation of energy are needed in cancer cell migration/invasion. After 24 h treatment, cordycepin suppresses epithelial-mesenchymal transition and migration in ovarian carcinoma cells through inhibiting estrogen-related receptor (ERR)-alpha. The ERRa is a co-transcription factor for gene expressions associated with mitochondrial fusion. Our results indicate that cordycepin suppresses metastasis and migration of ovarian carcinoma cells via inhibiting mitochondrial activity in non-toxic concentrations, and cordycepin has potential benefits in ovarian cancer therapy.

• 出版日期2017-1-10