A short and convenient strategy for the synthesis of pyridazines via Diaza-Wittig reaction

作者:Abed Hassen Bel; Mammoliti Oscar; Van Lommen Guy; Herdewijn Piet*
来源:Tetrahedron Letters, 2012, 53(48): 6489-6491.
DOI:10.1016/j.tetlet.2012.09.059

摘要

A convenient and selective synthesis of 6-substituted-4-hydroxy-3-methoxycarbonyl pyridazines has been developed via a diaza-Wittig reaction. The desired products substituted at the C6 position can be obtained from readily available starting materials under mild conditions. This represents an attractive new method for the synthesis of pyridazine derivatives.