Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products

作者：Hazra Abhijit; Mondal Shyamal; Maity Arindam; Naskar Subhendu; Saha Pritam; Paira Rupankar; Sahu Krishnendu B; Paira Priyankar; Ghosh Soma; Sinha Chandrima; Samanta Amalesh; Banerjee Sukdeb; Mondal Nirup B^*

来源：European Journal of Medicinal Chemistry, 2011, 46(6): 2132-2140.

DOI：10.1016/j.ejmech.2011.02.066

• Indolizines
• Pyrrolo quinolines/isoquinolines
• Amberlite-IRA-402 (OH)
• Dipolar cycloaddition
• Antibacterial
• Antifungal

A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived from the reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberlite IRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy.

• 出版日期2011-6