A novel approach to preparing magnetic protein microspheres with core-shell structure

作者：Jiang Wei^*; Sun Zhendong; Li Fengsheng; Chen Kai; Liu Tianyu; Liu Jialing; Zhou Tianle; Guo Rui

来源：Journal of Magnetism and Magnetic Materials, 2011, 323(5): 435-439.

DOI：10.1016/j.jmmm.2010.09.039

• Magnetic protein microsphere
• Solvent evaporation method
• Sonochemical method
• Magnetic nanoparticle
• Ferrofluid

Magnetic protein microspheres with core-shell structure were prepared through a novel approach based on the sonochemical method and the emulsion solvent evaporation method. The microspheres are composed of the oleic acid and undecylenic acid modified Fe(3)O(4) cores and coated with globular bovine serum albumin (BSA). Under an optimized condition, upto 57.8 wt% of approximately 10 nm superparamagnetic Fe(3)O(4) nanoparticles could be uniformly encapsulated into the BSA microspheres with the diameter of approximately 160 nm and the high saturation magnetization of 38.5 emu/g, besides of the abundant functional groups. The possible formation mechanism of magnetic microspheres was discussed in detail.

• 出版日期2011-3
• 单位南京理工大学