Anchors aweigh: protein localization and transport mediated by transmembrane domains

作者：Cosson Pierre^*; Perrin Jackie; Bonifacino Juan S

来源：Trends in Cell Biology, 2013, 23(10): 511-517.

DOI：10.1016/j.tcb.2013.05.005

• transmembrane domains
• protein sorting
• protein traffic
• lipid domains
• transmembrane receptors
• endomembrane system

The transmembrane domains (TMDs) of integral membrane proteins have emerged as major determinants of intracellular localization and transport in the secretory and endocytic pathways. Unlike sorting signals in cytosolic domains, TMD sorting determinants are not conserved amino acid sequences but physical properties such as the length and hydrophilicity of the transmembrane span. The underlying sorting machinery is still poorly characterized, but several mechanisms have been proposed, including TMD recognition by transmembrane sorting receptors and partitioning into membrane lipid domains. Here we review the nature of TMD sorting determinants and how they may dictate transmembrane protein localization and transport.

• 出版日期2013-10