Atropine Eye Drops: An Unusual Homicidal Poisoning

作者：Carlier Jeremy^*; Escard Emmanuel; Peoc'h Michel; Boyer Baptiste; Romeuf Ludovic; Faict Thierry; Guitton Jerome; Gaillard Yvan

来源：Journal of Forensic Sciences, 2014, 59(3): 859-864.

DOI：10.1111/1556-4029.12412

• atropine
• case report
• homicide
• ultrahigh-performance liquid chromatography/tandem mass spectrometry
• hair
• forensic toxicology
• forensic science

In March 2009, the body of a 51-year-old man was found in the boot of his car. The body had been frozen before being dismembered at the abdomen. The autopsy failed to determine the cause of death. Systematic toxicological analyses of the victim's peripheral blood and urine showed the presence of atropine, a powerful anticholinergic. Atropine was therefore specifically detected and quantified throughout the victim's biologic samples by HPLC-MS2 in the biologic fluids and UHPLC-MS2 in the hair. The atropine concentrations were 887ng/mL in the cardiac blood, 489ng/mL in the peripheral blood, 6693ng/mL in the gastric contents (1.1 mu g), 6753ng/mL in the urine, and 2290pg/mg in the hair. The blood concentrations measured in the decedent were consistent with an overdose of atropine, which was determined as the cause of death. The manner of death was a homicide with criminal intent.

• 出版日期2014-5