Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity

作者：Donlon Timothy A; Morris Brian J^*; He Qimei; Chen Randi; Masaki Kamal H; Allsopp Richard C; Willcox D Craig; Tranah Gregory J; Parimi Neeta; Evans Daniel S; Flach**art Friederike; Nebel Almut; Kim Duk Hwan; Park Joobae; Willcox Bradley J

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2017, 72(8): 1038-1044.

DOI：10.1093/gerona/glw116

• Connective tissue growth factor
• Epidermal growth factor
• Case-control study
• Molecular genetics
• Longevity

Growth pathways play key roles in longevity. The present study tested single-nucleotide polymorphisms (SNPs) in the connective tissue growth factor gene (CTGF) and the epidermal growth factor receptor gene (EGFR) for association with longevity. Comparison of allele and genotype frequencies of 12 CTGF SNPs and 41 EGFR SNPs between 440 American men of Japanese ancestry aged >= 95 years and 374 men of average life span revealed association with longevity at the p <.05 level for 2 SNPs in CTGF and 7 in EGFR. Two in CTGF and two in EGFR remained significant after Bonferroni correction. The SNPs of both CTGF and EGFR were in a haplotype block in each respective gene. Haplotype analysis confirmed the suggestive association found by.2 analysis. We noted an excess of heterozygotes among the longevity cases, consistent with heterozygote advantage in living to extreme old age. No associations of the most significant SNPs were observed in whites or Koreans. In conclusion, the present findings indicate that genetic variation in CTGF and EGFR may contribute to the attainment of extreme old age in Japanese. More research is needed to confirm that genetic variation in CTGF and EGFR contributes to the attainment of extreme old age across human populations.

• 出版日期2017-8