Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers

作者：Barros Mangueira Liane Franco; Nunes Ramalho Luciana da Silva; Lira Andressa Brito; Ramalho Josue do Amaral; Oliveira Kardilandia Mendes; Pimentel de Almeida Torres Aretuza Iolanda; Vasconcelos do Nascimento Valerio Marcelo; Bezerra Luna Lima Caliandra Maria; Soares Aragao Cicero Flavio; Formiga Melo Diniz Margareth de Fatima

来源：Brazilian Journal of Pharmacognosy, 2015, 25(5): 491-498.

DOI：10.1016/j.bjp.2015.06.009

• Clinical
• Cissampelos sympodialis
• Menispermaceae
• Tea

Cissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant.

• 出版日期2015-10