A versatile method for evaluating the controlled-release performance of microcapsules

作者：Cui, Kai-di; Li, Bei-xing; Huang, Xue-ping; He, Lei-ming; Zhang, Da-xia; Mu, Wei; Liu, Feng^*

来源：Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2017, 529: 80-87.

DOI：10.1016/j.colsurfa.2017.05.060

• Microcapsule
• Dissolution test
• Release
• Syringe filters
• Wall material

Sustained-release profile is an important component in the quality control of microcapsules. In the current study, we propose a reliable, convenient, and versatile strategy to assess the controlled-release performance of MCs under artificial, simulated conditions. Dissolution tests were performed using an experimental device equipped with syringe filters. The optimum experimental conditions utilized 80% v/v methanol (3 ml) as a release medium at each sampling point, Nylon 6 filters (13 mm diameter, 0.22 mu m pore size) as diffusion barriers, and a sampling regime based on predetermined changed intervals. Validation tests demonstrated that this strategy possessed favorable universality for three wall materials (polyurea, polyurethane and urea-formaldehyde) and three core materials (phoxim, pyraclostrobin and clomazone), as all sampling points had standard errors below 3.4%. Our proposed method also showed apparent advantages in experimental precision and the demand for a release medium compared with dynamic dialysis.

• 出版日期2017-9-20
• 单位山东农业大学